Screening test for hydrindicuria.
نویسندگان
چکیده
VEil-GROWING evidence indicates that time indole nmetabohsm imas a major role in mental illness. in i)levious publications (1, 2) we reported time i(lemmtification, isolation, and the pui-ificatiomm of some unusual iimdolic substances from the urine of a nmentally ill child. It was foummd that the chi-ornogeim of the emid pm-oduct was hydrindic acid, and the intermediate substances were dem-ived fi-oin aberration of the melanimm biosynthesis. Timis paper describes a screening test, which may be usefiii for time detection of disorders of similar or identical etiology. Time test consists of time acidification of time urine sample followed by isobutalmol extm-action of the pigment, removal of the impurities by washimmgs of time extract and by reextractiomm into the alkaline phase. Quantitative determination is made i)y photometry. In all consistently positive cases a more thorough investigation is immdicated, as noted previously (1).
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عنوان ژورنال:
- Clinical chemistry
دوره 12 9 شماره
صفحات -
تاریخ انتشار 1966